Gene constraint for one gene — gnomad

How intolerant a gene is to variation. pli and loeuf summarize loss-of-function intolerance; the Z-scores summarize missense and synonymous depletion.

Usage

gnomad_constraint(symbol, reference_genome = "GRCh38", ...)

Arguments

symbol: A gene symbol.
reference_genome: "GRCh38" or "GRCh37".
...: Passed to biohttp::post_json(), for example throttle.

Value

A biohttp envelope whose data is a one-row tibble. See gnomad_parse_constraint().

Examples

if (FALSE) { # \dontrun{
biohttp::body_or_null(gnomad_constraint("BRAF"))
} # }