Pure. Takes an already-parsed response body and never touches the network.
Usage
gnomad_parse_constraint(body, symbol = NA_character_)
Arguments
- body
A parsed gnomAD GraphQL response body.
- symbol
The gene symbol that was queried.
Value
A one-row tibble with symbol, pli, loeuf, oe_lof, oe_mis,
mis_z, syn_z, and lof_z. NULL when the gene has no constraint
block, which is common and is an answer rather than a fault.
Details
loeuf is gnomAD's oe_lof_upper. The two names are the same number, and
the field is called oe_lof_upper in the API but LOEUF everywhere else,
including in the ranking models that consume it. Both names appear here so a
reader of either can find it.
Examples
body <- list(data = list(gene = list(
gnomad_constraint = list(pli = 1, oe_lof_upper = 0.23)
)))
gnomad_parse_constraint(body, "BRAF")
#> # A tibble: 1 × 8
#> symbol pli loeuf oe_lof oe_mis mis_z syn_z lof_z
#> <chr> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl>
#> 1 BRAF 1 0.23 NA NA NA NA NA
