The default rate limit for VEP requests

Ensembl publishes no formal limit for the REST service, but an unpaced burst of the 100 or so requests one case's coding lane needs reliably trips a 429 partway through. One request per second is conservative enough to avoid that while still finishing a typical chunk count in a few minutes; vep_variants_all() applies it by default.

Usage

vep_default_throttle()

Value

A throttle spec, see biohttp::req_defaults()'s throttle argument.

References

McLaren et al. (2016). The Ensembl Variant Effect Predictor. Genome Biology 17, 122. doi:10.1186/s13059-016-0974-4

Service documentation: https://rest.ensembl.org/

Examples

vep_default_throttle()
#> $capacity
#> [1] 1
#> 
#> $fill_time_s
#> [1] 1
#>