Diseases associated with a gene — opentargets_gene

Takes an Ensembl gene id, not a symbol, because that is what the Open Targets target query accepts. Resolve a symbol first with mygene_gene() and read its ensembl_gene column.

Usage

opentargets_gene_diseases(ensembl_id, size = 20, ...)

Arguments

ensembl_id: An Ensembl gene id, for example "ENSG00000141510".
size: How many associations to ask for.
...: Passed to biohttp::post_json(), for example throttle.

Value

A biohttp envelope whose data is the tibble described in opentargets_parse_diseases().

Details

Keeping the resolution out of this function is deliberate. A client that silently made a second call to a different service would make one failure look like the other's, and a MyGene outage would read as an Open Targets outage.

References

Buniello et al. (2025). Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery. Nucleic Acids Research 53(D1), D1467-D1475. doi:10.1093/nar/gkae1128

Service documentation: https://platform.opentargets.org/

Examples

# \donttest{
biohttp::body_or_null(opentargets_gene_diseases("ENSG00000141510"))
#> # A tibble: 20 × 4
#>    disease                                    disease_id    score source_url    
#>    <chr>                                      <chr>         <dbl> <chr>         
#>  1 Li-Fraumeni syndrome                       MONDO_0018875 0.876 https://platf…
#>  2 hepatocellular carcinoma                   MONDO_0007256 0.797 https://platf…
#>  3 head and neck squamous cell carcinoma      MONDO_0010150 0.777 https://platf…
#>  4 choroid plexus papilloma                   MONDO_0009837 0.766 https://platf…
#>  5 colorectal cancer                          MONDO_0005575 0.750 https://platf…
#>  6 basal cell carcinoma, susceptibility to, 7 MONDO_0013876 0.740 https://platf…
#>  7 hereditary breast carcinoma                MONDO_0016419 0.740 https://platf…
#>  8 esophageal cancer                          MONDO_0007576 0.729 https://platf…
#>  9 lung adenocarcinoma                        MONDO_0005061 0.727 https://platf…
#> 10 adrenal cortex carcinoma                   MONDO_0006639 0.723 https://platf…
#> 11 acute myeloid leukemia                     MONDO_0018874 0.723 https://platf…
#> 12 choroid plexus carcinoma                   MONDO_0016718 0.722 https://platf…
#> 13 adrenocortical carcinoma, hereditary       MONDO_0008734 0.714 https://platf…
#> 14 bone osteosarcoma                          MONDO_0002629 0.713 https://platf…
#> 15 glioblastoma                               MONDO_0018177 0.711 https://platf…
#> 16 breast adenocarcinoma                      MONDO_0004988 0.709 https://platf…
#> 17 urinary bladder cancer                     MONDO_0001187 0.704 https://platf…
#> 18 basal cell carcinoma                       MONDO_0020804 0.704 https://platf…
#> 19 bone marrow failure syndrome               MONDO_0000159 0.698 https://platf…
#> 20 familial pancreatic carcinoma              MONDO_0015278 0.697 https://platf…
# }